PDF | Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Abstract, Full, Pdf. Apr , 3, 0, 0. May , 4, 0, 1. Jun , 2, 0, 0. Jul , 19, 0, 2. Aug , 21, 0, 1. Sep , 47, 0, 0. Oct , , 0, Nov PubMed journal article Linkage of early-onset familial breast cancer to chromosome 17q2 were found in PRIME PubMed. Download Prime PubMed App to.
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Linkage of early-onset familial breast cancer to chromosome 17q
National Center for Biotechnology InformationU. Familial breast-ovarian cancer locus on chromosome 17qq Strategies 17q12 multilocus linkage analysis in humans. This article has been cited by other articles in PMC.
This article has been corrected. There is probably more than one gene for inherited breast cancer, but heterogeneity may not be due to age at disease onset. Support Center Support Center. Closing in on a breast cancer gene on chromosome 17q. Am J Hum Genet. Linkage of early-onset familial breast cancer to chromosome 17q See Am Familkal Hum Genet.
Linkage of early-onset familial breast cancer to chromosome 17q21.
Author information Copyright and License information Disclaimer. Genetic epidemiology of breast cancer in Britain.
Inheritance of human breast cancer: Genetic epidemiology of breast cancer: Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families familiak disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease.
– Document – Linkage of early-onset familial breast cancer to chromosome 17q21
A new statistical test for linkage heterogeneity. Inheritance of proliferative breast disease in breast cancer kindreds. Segregation and linkage analysis of nine Utah breast cancer pedigrees. Associated Data Supplementary Materials.
Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.
The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. If this correction is made, then later-onset families are much less informative; linkage heterogeneity based on age at onset is no longer significant; and for the sample of families as a whole, linkage is significant at a recombination fraction since demonstrated to be close to the correct local.
However, for late-onset cases, the relative probability of sporadic rather than inherited disease is higher than previously suggested.
Estimating the power of linkage analysis in hereditary breast cancer. Open in a separate window. Genetic analysis of breast cancer in the cancer and steroid hormone study.