Guidelines regarding constitution / reconstitution of IAEC 48th Meeting of CPCSEA was held on 21st August, under the Chairmanship of Shri Hem. PDF | The effect of implementation of guidelines of the Committee for the Purpose of Control and The results showed that the implementation of CPCSEA guidelines in pharmacy institution . Mar ; J Indian Assoc Pediatr Surg. PDF | On Dec 29, , Pandey Govind and others published Guidelines of CPCSEA for conducting the experiment on animals.

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Animal use in pharmacology education and research: The changing scenario

Similarly, the response of faculty in India to training on alternatives guidelinrs very encouraging. Typical experiments included effect of drugs on rabbit intestine, rabbit eye, central nervous system, reproductive system, as also the frog heart and frog rectus.

guivelines We evaluated these software programs and found that the alternatives are implementable and decrease the cost and time spent guidrlines animal experiments. Animal rights [Wikipedia] [Last accessed on May 30]. To use standard view, enable JavaScript by changing your browser options, then try again. Student evaluation of teaching and assessment methods in pharmacology. The upgraded versions of the earlier software programs are available but no innovative comprehensive software has been introduced so far.

The biological effects in the eye are easier to visualize because of lesser tear flow and absence of gyidelines pigment in these animals. A chronology of animal protection laws. Development of alternatives to animal experiments in teaching seems less tedious.


Chitosan films, a substitute for animal and human epidermal sheets are used for in vitro permeation of polar and non-polar drugs. Human skin cells have been cultured to produce a model of human skin like EpiDerm and EpiSkin.

Animal use in pharmacology education and research: The changing scenario

Distillery Unit at Vill. Animal experiments, for long, have been an integral part of the pharmacology cpceea at medical colleges in India. While a combination of newer in vivo and in vitro techniques do provide viable and cost-effective alternatives to certain pharmacodynamic and pharmacokinetic evaluations of drugs, animal testing is yet required for repeat dose toxicity, carcinogenicity of drugs and certain behavioral studies.

These techniques guideines be efficiently used to screen highly toxic compounds at an early stage. Invertebrates can be used to replace the more commonly used laboratory animals. What is animal experimentation? So how do we judge the ethical issues in animal experimentation?

In India, two models are currently available: A survey of animal use and alternatives in higher education in Europe. The use of live animal experiments is decreasing in many medical colleges across India. In spite of some obvious drawbacks like the lack of an adaptive immune system which is a deterrent for their use in certain types of research such as vaccine development, these organisms do have a potential as alternatives to use of conventional animals. Guidelines for care and use of animals in scientific research.


Microdosing studies enable potential new drugs to be tested safely in humans using ultrasensitivity of accelerator mass spectrometry. While the idea seems interesting and feasible, realizing, testing and validating an alternative method from idea to approval can be tedious and time consuming. A global assessment by pharmacology faculties and MBBS students? A larger number and a greater variety of animals are used in pure research than in applied research.

These laboratory animals are obtained from gguidelines sources in different countries. Alternatives to animals in education, research and risk assessment: To add to this, withdrawal and ban of a number of drugs in recent years including rofecoxib, which was proven safe in animal testing highlight these legitimate concerns about extrapolation of animal test results to human beings.

These are mechanistic models that aim to predict sensitization from mechanistic knowledge and empirical models that are aimed at predicting from a statistical perspective.

Also, high doses of chemicals are used in a small number of laboratory animals to predict the effects of low doses in large number of humans. Several students objected openly against animal dissection exercises thereafter. After validation, acceptance of the alternative is necessary for its success.

Similarly, fruit flies can be useful to identify novel virulence factors or pharmacologically active compounds. Replacement methods can be absolute replacements i.

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