Fibrolamellar hepatocellular carcinoma (FHCC) is a rare form of hepatocellular carcinoma (HCC) that typically affects young adults and is characterized, under. Although fibrolamellar carcinoma (FLC) has conventionally been considered to be a histologic variant of hepatocellular carcinoma (HCC). Summary. An Orphanet summary for this disease is currently under development. However, other data related to the disease are accessible.

Author: Samuzilkree Tatilar
Country: Barbados
Language: English (Spanish)
Genre: Spiritual
Published (Last): 13 May 2008
Pages: 276
PDF File Size: 3.51 Mb
ePub File Size: 17.74 Mb
ISBN: 170-2-50197-811-6
Downloads: 78628
Price: Free* [*Free Regsitration Required]
Uploader: Miramar

Only comments written in English can be processed. Nepatocelular detailed report on frequency, treatment and outcome based on the surveillance, epidemiology, and end results database. Immunohistochemical studies have found that FL-HCC expresses markers associated with biliary CK7 and epithelial membrane antigen and hepatic hepar-1 and glypican-3 differentiation as well as markers associated with hepatic stem cells CD and CD44 that help differentiate it from conventional HCC [ 1213 ]. These include the presence of sheets of large polygonal or spindle-shaped tumor cells with abundant granular eosinophilic cytoplasm, prominent nuclei, and paucicellular fibrous stroma arranged in thin parallel lamellae around tumor cells.

Metastatic Fibrolamellar Hepatocellular Carcinoma to the Pancreas

The patient was then referred for evaluation and diagnosis of the pancreatic mass by endoscopic ultrasound-guided fine-needle aspiration EUS-FNA. Fibrolamellar hepatocellular carcinoma in children and adolescents.


Outcome of patients with fibrolamellar hepatocellular carcinoma. Summary and related texts. Rev Esp Enferm Dig ; In fact, a recent meta-analysis found that there seemed to be no difference in survival between FL-HCC and conventional HCC in noncirrhotic patients or when transplantation was used as the therapeutic option [ 17 ]. Gastrointestinal stromal tumor Krukenberg tumor metastatic.

Computed tomography of body with magnetic resonance imaging. National Center for Biotechnology InformationU. The patient was sent fibrklamelar us for diagnostic ultrasound-guided puncture.

Dear EditorHepatocellular carcinoma HCC catcinoma the most common primary malignant neoplasm of the liver, the sixth leading cause of cancer and the third leading cause of cancer death 1. We present the case of a year-old patient with metastatic FL-HCC to the pancreas 30 years after diagnosis and 26 years since his last resected liver recurrence.

Phase II trial of systemic continuous fluorouracil and subcutaneous recombinant interferon Alfa-2b for treatment of hepatocellular carcinoma. Cytologicallythe tumor cells have a low nuclear to cytoplasmic ratio with abundant eosinophilic cytoplasm.

Micrograph of fibrolamellar hepatocarcinoma showing the characteristic laminated fibrosis between the tumor cells with a low NC ratio. Estudo de Katzenstein et al. It is characterized histologically by well-differentiated malignant hepatic cells with abundant eosinophilic and granular cytoplasm due to the presence of numerous carcinnoma, and by the presence of fibrous stroma arranged in thin parallel lamellae interspersed between tumor cells [ 1 ]. Case 2 Case 2. In our patient, it recurred 30 years after he had first been diagnosed and 26 years since his last liver recurrence, which was treated with a liver transplant.

  KX T7703 PDF

Orphanet: Carcinoma hepatocelular fibrolamelar

Sleisenger and Fordtran, editors. Typically these tumours occur in young adults 20 to 40 years of age without gender predilection. His AFP level was normal. Support Radiopaedia and see fewer ads. Please review our privacy policy.

The tumor cells are arranged in cords that are separated by sheetlike fibrous bands arranged in a parallel or lamellar distribution 4: Hepatology ; 39 3: Radiotherapy has been used but data is limited concerning its use. Cancer ; 6: For all other comments, please send your remarks via contact us. Fibrolamellar hepatocellular carcinoma presenting with Budd-Chiari syndrome, right atrial thrombus, and pulmonary emboli.

The patient was then referred to surgery for resection of his lung nodule and pancreatic tail mass. J Am Coll Surg. hepatoceular

Although recurrences and metastasis are common, surgery is still the treatment of choice for resectable metastasis, given the lack of other effective treatment options such as chemotherapy [ 46 ].

Author: admin