ALBIOS: Albumin Replacement in Patients with Severe Sepsis or Septic Shock Randomised, controlled clinical trial; Stratified according to. In this icTV interview video, Luciano Gattinoni discusses his recent trial: Albumin for Volume Replacement in Severe Sepsis (ALBIOS). BACKGROUND: A reanalysis of the ALBIOS trial suggested that patients with septic shock – defined by vasopressor-dependent hypotension in.

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thinking critical care

As the authors note, mortality was low, organ failure was low, so study power a little low as well. Another interesting thing would have been to know the infusion time of the albumin, since animal data tells us that a 3hr infusion decreases extravasation and improves vascular filling vs shorter infusion times. I routinely insist on 3hr infusion per unit, which sometimes results in hr infusions, almost albumin drips!

I think this is actually a really good study on which to base assessment albkos more aggressive vasopressor support vs fluid resuscitation, in the right patients. Follow me albioa Twitter My Tweets.

ALBIOS – Wiki Journal Club

Human nature for some I guess. They also note the underpowered-ness of their own study, but I think it is still worth looking at their results. Sorry, your blog cannot share posts by email. He describes the objectives hrial reports early results from this sepsis trial and suggests that while they are still awaiting conclusive results, perhaps findings may show that there are specific patient groups in which treatment with Albumin may prove to be beneficial.


As the authors note, the actual BP averages were higher albioss planned.

Choice of Fluid- John Myburgh Summary. In my mind the benefit of albumin would be greatest in those with significant capillary leak, particularly those with intra-abdominal and pulmonary pathology.

The ALBIOS study a Gattinoni crew So basically showed no difference, so pretty much a solid italian remake of the SAFE study in a sense, confirming that albumin is indeed safe overall, and may be better in those with shock.

So basically showed no difference, so pretty much a solid italian remake of the SAFE study in a sense, confirming that albumin is indeed safe overall, and may be better in those with shock. It would have been nice to see a subgroup analysis where extravascular lung water was looked at especially coming from a Gattinoni crew!

Lactate Clearance…more weight to the argument?

A large randomized controlled trial to evaluate for benefit of albumin in patients with severe sepsis or septic shock was lacking. We compared the Shock-2 and the Shock-3 definitions and the albumin and crystalloid treatment groups in terms of group size and physiological, laboratory and outcome variables. Courtesy of Felix Albumin decreased mortality in Shock-2 patients compared to crystalloids So basically a negative study except for two findings, the increased incidence of afib in the high target group and the decreased need for renal replacement therapy among chronic hypertensives in the high target group.

Patients treated in the albumin group had a shorter duration on vasopressors or inotropes and improved cardiovascular parameters early in their ICU course. Republished by Blog Post Promoter. A subgroup analysis of the secondary outcome of 90 day all-cause mortality demonstrated a survival advantage for albumin therapy in those in septic shock at enrollment.


Early fluids were administered according to EGDT protocol. A pilot trial by Dubois et al. Meets criteria for SIRS.

Hi Jonathan, I have to confess my current views on albumin are ambivalent, given recent discussions with Tom Woodcock and the concern with the glycocalyx… I am hoping for more research on this to be available, so although I still use it, I do so less than before. Get my feet to the floor…please! Your email address will not be published. Ok, so it was pretty cool to see an NEJM issue basically dedicated to septic shock management, I must admit. We compared group size, physiological variables and day mortality between patients defined by Shock-2 and Shock-3 and between the albumin and crystalloid treatment groups.

Multi centre, open label.

ALBIOS – The Bottom Line

They also used a target albumin level, not albumin as a resuscitation fluid purely. Luigi Gonzaga, Orbassano, Italy. Usable articles Critical Care.

Both groups were treated with crystalloids as needed. Notify me of new posts by email. Retrieved from ” http: The New England Journal of Medicine.

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